Publications

Cartoon depiction of active transport process

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Preprint

Secondary Active Transport Driven by a Lipophilicity Gated Compartmentalised Chemical Reaction

G Kaur^†, I. V. Smolyar^†, I. Moss, E. Grählert, and M. J. Langton*, ChemRxiv, 2026

^†Contributed equally

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Preprint

Mechanism of Phosphoinositide Regulation of Lysosomal pH via Inhibition of CLC-7

J. K. Hilton, Y. Lin, E. Sefah, J. C. Deme, J. L. Parker, M. J. Langton, M. Grabe, S. Lea, S. Newstead, and J. A Mindell*, BioRxiv, 2025

Cartoon depiction of transporter-mediated contrast activity in dual wrapped MSNs

55.

Ion Transport Mediated pH-responsive MRI Contrast in Dual Wrapped MSNs

J. P. Smith^†, A. Duncan^†, C. M. Ellis, A. Kerckhoffs, M. J. Langton, and J. J. Davis, Accepted Manuscript

^†These authors contributed equally.

Cartoon depiction of inter-vesicular transport process

54.

Dual-Stimuli Responsive Ionophore for OFF-ON-OFF Transmembrane Calcium Ion Transport and Inter-Vesicle Signalling

G. Kaur, K. M. Bąk, D. C. Edwards, S. L. Cockroft, M. H. Horrocks, and M. J. Langton*, Chem. Sci., 2026

Cartoon depiction of photo-activated transport process

53.

Near-Infrared Triggered Anion Transport Induces Cancer Cell Death

M. Ahmad, R. M. Devereuxa, A. J. Russell, and M. J. Langton*, Angew. Chem. Int. Ed., 2026, 65, e23734

52.

Speciation and Luminescence of a Binuclear Lanthanide Complex Bearing an Aminophenolate Chromophore

V. R. M. Nielsen, C. H. Simms, D. Kovacs, M. F. Allen, M. J. Langton, S. Faulkner*, and T. J. Sørensen*, Chem. Eur. J., 2025, 31, e02305

51.

Organic functionality in responsive paramagnetic nanostructures

A. M. Duncan, C. M. Ellis, J. P. Smith, L. Leutloff, M. J. Langton, and J. J. Davis*, Front. Chem., 2025, 13, 1605538

Cartoon depiction of stimuli-responsive transport process

50.

Responsive anion transport with a Hamilton receptor-based anionophore controlled by photo-activation and host-guest competitive inhibition

(Featured in the Chem. Sci. 15th Anniversary: Chemical Science Leading Investigators collection)

M. Ahmad, A. Docker, and M. J. Langton*, Chem. Sci., 2025, 16, 13715-13722

49.

Ion transport across biological membranes

R. S. Bon* and M. J. Langton*, Curr. Op. Chem. Bio., 2025, 87, 102606

48.

Chloride Selective, Non-protonophoric Ion Transport with Macrocyclic Halogen Bonding Anionophores

M. Flerin, F. Duarte*, and M. J. Langton*, Chem. Eur. J., 2025, 31, e202502033

Chemical structures of lanthanide complexes

47.

Binuclear lanthanide complexes as magnetic resonance and optical imaging probes for redox sensing

C. H. Simms, D. Kovacs, L. Hacker, E. T. Sarson, D. Sokolova, K. E. Christensen, A. Khrapichev, L. Martin, K. Vincent, S. J. Conway, E. M. Hammond*, M. J. Langton*, and S. Faulkner*, Chem. Eur. J., 2025, 31, e202404748

46.

ON-OFF nanopores for optical control of transmembrane ionic communication

X. Wang, A. Kerckhoffs, J. Riexinger, M. Cornall, M. J. Langton*, H. Bayley*, and Y. Qing*, Nat. Nanotechnol., 2025, 20, 432-440

Cartoon depiction of relay transport process

45.

Transmembrane Delivery of an Aryl Azopyrazole Photo-switchable Ion Transporter Relay

("Hot" paper)

E. Grählert, and M. J. Langton*, Angew. Chem. Int. Ed., 2025, 64, e202421580

44.

Off-On Photo- and Redox-Triggered Anion Transport Using an Indole-Based Hydrogen Bond Switch

M. Ahmad, A. Muir, and M. J. Langton*, ACS Omega, 2024, 9, 45572-45580

43.

Stimuli-responsive anion transport utilising caged hydrazone-based anionophores

M. Ahmad, M. Flerin, H. M. Tay, A. L. Thompson, F. Duarte*, and M. J. Langton*, Nanoscale, 2024, 16, 21545-21553

42.

Transient Photoactivation of Anionophores by Using Redshifted Fast-Relaxing Azobenzenes

A. Kerckhoffs, M. Ahmad, and M. J. Langton*, Chem. Eur. J., 2024, 30, e202402382

41.

Ion carrier modulated MRI contrast

A. M. Duncan, C. M. Ellis, H. Levingston, A. Kerckhoffs, F. E. Mozes, M. J. Langton, and J. J. Davis*, Chem. Sci., 2024, 15, 13937-13941

40.

Length dependent reversible off-on activation of photo- switchable relay anion transporters

(Hot article and featured in Chem. Commun. 60th anniversary collection)

T. G. Johnson, A. Sadeghi-Kelishadi, M. J. Langton*, Chem. Commun., 2024, 60, 7160-7163

Cartoon depiction of photoswitchable control

39.

Photoswitchable Luminescent Lanthanide Complexes Controlled and Interrogated by Four Orthogonal Wavelengths of Light

C. Simms, V. R. M. Nielsen, T. J. Sørensen, S. Faulkner*, and M. J. Langton*, Phys. Chem. Chem. Phys., 2024, 26, 18683-18691

38.

Responsive Anionophores with AND Logic Multi-Stimuli Activation

("Hot" paper)

M. Ahmad, T. G. Johnson, M. Flerin, F. Duarte, and M. J. Langton*, Angew. Chem. Int. Ed., 2024, 63, e202403314

Cartoon depiction of transport and catalysis process

37.

Coupling Photoresponsive Transmembrane Ion Transport with Transition Metal Catalysis

X. Chao^†, T. G. Johnson^†, M. Temian, A. Docker, A. L. D. Wallabregue, A. Scott, S. J. Conway, and M. J. Langton*, J. Am. Chem. Soc., 2024, 146, 4351-4356

^†These authors contributed equally.

36.

Molecular Machines for the Control of Transmembrane Transport

T. G. Johnson and M. J. Langton*, J. Am. Chem. Soc., 2023, 50, 27167-27184

Cartoon depiction of anion binding process

35.

Exploiting the Catenane Mechanical Bond Effect for Selective Halide Anion Transmembrane Transport

H. M. Tay, T. G. Johnson, A. Docker, M. J. Langton*, and P. D. Beer*, Angew. Chem. Int. Ed., 2023, 62, e202312745

34.

Inter-vesicle Signal Transduction Using a Photo-responsive Zinc Ionophore

("Hot" paper)

S. A. Gartland, T. G. Johnson, E. Walkley, and M. J. Langton*, Angew. Chem. Int. Ed., 2023, 62, e202309080

33.

Photo- and Redox-regulated Transmembrane Ion Transporters

M. Ahmad, S. A. Gartland, and M. J. Langton*, Angew. Chem. Int. Ed., 2023, 62, e202308842

32.

Transmembrane Anion Transport Mediated by Sigma-Hole Interactions

A. Docker* and M. J. Langton*, Trends Chem., 2023, 5, 792-794

31.

Halogen Bonding Relay and Mobile Anion Transporters with Kinetically Controlled Chloride Selectivity

T. G. Johnson, A. Docker, A. Sadeghi-Kelishadi, and M. J. Langton*, Chem. Sci., 2023, 14, 5006-5013

30.

Multistate Redox-Switchable Ion Transport Using Chalcogen-Bonding Anionophores

A. Docker, T. G. Johnson, H. Kuhn, Z. Zhang, and M. J. Langton*, J. Am. Chem. Soc., 2023, 145, 2661-2668

Cartoon depiction of photoswitchable binding

29.

Photo-switchable Anion Binding and Catalysis with a Visible Light Responsive Halogen Bonding Receptor

("Hot" Article, emerging investigator collection)

A. Kerckhoffs, I. Moss, and M. J. Langton*, Chem. Commun., 2023, 59, 51-54

28.

Fast Relaxing Red and Near-IR Switchable Azobenzenes with Chalcogen and Halogen Substituents: Periodic Trends, Tunable Thermal Half-lives and Chalcogen Bonding

("Hot" Article and included in the Chemical Science 2022 most popular organic chemistry collection)

A. Kerckhoffs, K. E. Christensen, and M. J. Langton*, Chem. Sci., 2022, 13, 11551-11559

27.

Controlling Transmembrane Ion Transport via Photo-Regulated Carrier Mobility

("Hot" Article)

L. E. Bickerton and M. J. Langton*, Chem. Sci., 2022, 13, 9531-9536

26.

A Photo-responsive Transmembrane Anion Transporter Relay

T. G. Johnson, A. Sadeghi-Kelishadi, and M. J. Langton*, J. Am. Chem. Soc., 2022, 114, 10455-10461

25.

Red-shifted Tetra-ortho-halo-azobenzenes for Photo-regulated Transmembrane Anion Transport

(Highlighted in Synfacts)

A. Kerckhoffs, Z. Bo, S. E. Penty, F. Duarte*, and M. J. Langton*, Org. Biomol. Chem., 2021, 12, 11252-11274

24.

Supramolecular Chemistry in Lipid Bilayer Membranes

L. E. Bickerton^†, T. G. Johnson^†, A. Kerckhoffs^†, and M. J. Langton*, Chem. Sci., 2021, 12, 11252-11274

^†These authors contributed equally.

Cartoon depiction of anion binding and photoswitchable control

23.

Halogen Bonding Tetraphenylethene Anion Receptors: Anion-induced Emissive Aggregates and Photoswitchable Recognition

A. Docker^†, X. Shang^†, D. Yuan, H. Kuhn, Z. Zhang, J. J. Davis, P. D. Beer*, and M. J. Langton*, Angew. Chem. Int. Ed., 2021, 23, 19442-19450

^†These authors contributed equally.

22.

Highly Active Halogen Bonding and Chalcogen Bonding Chloride Transporters with Non-Protonophoric Activity

(Invited contribution to a special edition on "Non-covalent interactions")

L. E. Bickerton^†, A. Docker^†, A. J. Sterling, H. Kuhn, F. Duarte*, P. D. Beer*, and M. J. Langton*, Chem. Eur. J., 2021, 27, 11738-11745

^†These authors contributed equally.

21.

Engineering of Stimuli-responsive Lipid-bilayer Membranes using Supramolecular Systems

M. J. Langton*, Nat. Rev. Chem., 2021, 5, 46-61

20.

Reversible Photo-Control over Transmembrane Anion Transport Using Visible-Light Responsive Supramolecular Carriers

A. Kerckhoffs and M. J. Langton*, Chem. Sci., 2020, 11, 6325-6331

19.

Transmembrane Anion Transport Mediated by Halogen Bonding and Hydrogen Bonding Triazole Anionophores

L. E. Bickerton, A. J. Sterling, P. D. Beer*, F. Duarte*, and M. J. Langton*, Chem. Sci., 2020, 11, 4722-4729

Early career fellowship, DPhil, and MChem publications

18.

Triggered Release from Lipid Bilayer Vesicles by an Artificial Transmembrane Signal Transduction System

(Featured in "Chemical and Engineering News")

M. J. Langton*, L. M. Scriven, N. H. Williams, and C. A. Hunter, J. Am. Chem. Soc., 2017, 139, 15768-15773

17.

Recognition-controlled Membrane Translocation for Signal Transduction across Lipid Bilayers

M. J. Langton, N. H. Williams*, and C. A. Hunter*, J. Am. Chem. Soc., 2017, 139, 6461-6466

16.

Controlled Membrane Translocation Provides a Mechanism for Signal Transduction and Amplification

(Featured in News and Views: Nat. Chem., 2019, 9, 406-407, and the Nature Chemistry editorial 'Sending a message to the other side' Nat. Chem., 2017, 9, 403)

M. J. Langton, F. Keymeulen, M. Ciaccia, N. H. Williams*, and C. A. Hunter*, Nat. Chem., 2017, 9, 426-430

15.

Active-metal Template Synthesis of a Halogen Bonding Rotaxane for Anion Recognition

(Highlighted in Synfacts, 2016, 12, 257)

M. J. Langton, Y. Xiong, and P. D. Beer*, Chem. Eur. J., 2016, 21, 18910-18914

14.

Iodide Recognition and Sensing in Water by a Halogen Bonding Ruthenium(II)-based Rotaxane

("Hot paper")

M. J. Langton, I. Marques, S. W. Robinson, V. Félix, and P. D. Beer*, Chem. Eur. J., 2016, 22, 185-192

13.

Anion Recognition in Water: Recent Advances from a Supramolecular and Macromolecular Perspective

M. J. Langton, C. J. Serpell, and P. D. Beer*, Angew. Chem. Int. Ed., 2016, 55, 1974-1987

12.

Anion, Cation and Ion-pair Recognition by Macrocyclic and Interlocked Host Systems.

In Macrocyclic and Supramolecular Chemistry: How Izatt-Christensen Award Winners Shaped the Field; P. D. Beer and M. J. Langton, 2015, John Wiley & Sonts, Ltd., Chichester, UK.

11.

Chloride-Anion-Templated Synthesis of a Strapped-Porphyrin-Containing Catenane Host System

(Designated a "Hot paper" and featured in Chemistry Views)

A. Brown, M. J. Langton, N. L. Kilah, A. L. Thompson, and P. D. Beer*, Chem. Eur. J., 2015, 21, 17664-17675

10.

Halogen Bonding in Supramolecular Chemistry

L. C. Gilday, S. W. Robinson, T. A. Barendt, M. J. Langton, B. R. Mullaney, and P. D. Beer*, Chem. Rev., 2015, 115, 7118-7195

9.

Anion Recognition in Water by a Rotaxane Containing a Secondary Rim Functionalised Cyclodextrin Stoppered Axle

M. Rezanka, M. J. Langton, and P. D. Beer*, Chem. Commun., 2015, 51, 4499-4502

8.

Halogen Bonding in Water Results in Enhanced Anion Recognition in Acyclic and Rotaxane Hosts

(Selected for journal front cover pictures Dec. 2014, featured in News and Views: Nat. Chem., 2014, 6, 1029-1031)

M. J. Langton, S. W. Robinson, I. Marques, V. Félix and P. D. Beer*, Nat. Chem., 2014, 6, 1039-1043

7.

Nitrite-Templated Synthesis of Lanthanide-Containing [2]Rotaxanes for Anion Sensing

M. J. Langton, O. A. Blackburn, T. Lang, S. Faulkner, and P. D. Beer*, Angew. Chem. Int. Ed., 2014, 53, 111463-11466

6.

Nitrate Anion Templated Synthesis of a [2]Catenane for Nitrate Recognition in Organic-Aqueous Solvent Media

M. J. Langton and P. D. Beer*, Chem. Commun., 2014, 50, 8124-8127

5.

Rotaxane and Catenane Host Structures for Sensing Charged Guest Species

M. J. Langton and P. D. Beer*, Acc. Chem. Res., 2014, 47, 1935-1949

4.

Nitrate Anion Templated Assembly of a [2]Rotaxane for Selective Nitrate Recognition in Aqueous Solvent Mixtures

M. J. Langton, L. C. Duckworth, and P. D. Beer*, Chem. Commun., 2013, 49, 8608-8610

3.

Lanthanide-cation Templated Synthesis of Rotaxanes

F. Zapata, O. Blackburn, M. J. Langton, S. Faulkner, and P. D. Beer*, Chem. Commun., 2013, 49, 8157-8159

2.

Sulfate-selective Binding and Sensing of a Fluorescent [3]Rotaxane Host System

M. J. Langton and P. D. Beer*, Chem. Eur. J., 2012, 18, 14406-14412

1.

Template-directed Synthesis of π- conjugated Porphyrin [2]rotaxanes and a [4]catenane based on a six-porphyrin nanoring

(Selected for journal cover)

M. J. Langton, J. D. Matichak, A. L. Thompson, and H. L. Anderson*, Chem. Sci., 2011, 2, 1897-1901